Tuesday, April 21, 2020

Characterization of a catalase from red-lip mullet (Liza haematocheila): Demonstration of antioxidative activity and mRNA upregulation in response to immunostimulants.

Reactive oxygen species, generated in all the aerobic organisms, can cause oxidative stress. Excessive ROS may become a source of carcinogen due to DNA damage, lipid peroxidation, cell injury, and cell death. In order to prevent these adverse effects of ROS, antioxidant enzymes have evolved in aerobic organisms. Catalase is a major antioxidant enzyme that breaks down excessive H2O2 and inhibits apoptotic cell death. Here we molecularly characterized catalase from red-lip mullet. The cDNA sequence of LhCAT consists of an ORF of 1545?bp, which encodes a 527 amino acid peptide (~60?kDa). Based on bioinformatics analysis, LhCAT possesses a domain architecture…

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