July 30, 2015  |  

Clinical NGS 

PacBio CSO Jonas Korlach discusses the implications for SMRT Sequencing in clinical research.


July 9, 2015  |  

SMALR Bacterial Epigenetics

Researchers have reported an important advance for using SMRT sequencing for epigenetic studies with a new approach capable of probing epigenetic heterogeneity in a population of seemingly identical bacteria.


June 29, 2015  |  

Human Genome Sequenced without Cloning Steps

A collaboration of scientists led by researchers from Icahn School of Medicine at Mt. Sinai has created a comprehensive analysis of a diploid human genome using two complementary single DNA molecule methods for sequencing and genome mapping, and without the need for any DNA amplification techniques.


April 20, 2015  |  

Tapping the Yeast Genome

Cover Story – Researchers are bringing advanced technologies like SMRT Sequencing to improve the ancient art of beer brewing.


March 3, 2015  |  

PacBio at AGBT

Pacific Biosciences held a star-studded workshop to show off the feats that can be accomplished with its SMRT (Single Molecule, Real-Time) sequencers, the instruments of choice for recovering long-range structural information on the genome.


March 1, 2015  |  

When Whole Genome Sequencing Doesn’t Give Us the Whole Genome

As its throughput and average read length have continued to increase, customers have been using the technology for larger and larger genomes. Now, a number of customers are using the technology to de novo sequence whole human genomes, according to presentations at last week’s AGBT meeting.


February 1, 2015  |  

Decoding the Unsequenceable

In case you’re not aware, the human genome is not completely sequenced. Regions of repeats and hard to decode sequence continue to elude scientists. And then there is the challenge of genetic variation. Nathan Blow looks at new technologies and methods that could help map these and other difficult-to-read stretches of DNA.


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