July 30, 2015 |
Clinical NGS
PacBio CSO Jonas Korlach discusses the implications for SMRT Sequencing in clinical research.
Asset Type: Media article
July 9, 2015 |
SMALR Bacterial Epigenetics
Researchers have reported an important advance for using SMRT sequencing for epigenetic studies with a new approach capable of probing epigenetic heterogeneity in a population of seemingly identical bacteria.
July 6, 2015 |
Following Feasibility Study, UK Registry Plans to Implement PacBio for HLA Typing by Year’s End
GenomeWeb: The UK’s Anthony Nolan Research Institute plans to start using Pacific Biosciences’ sequencing technology routinely for HLA typing by the end of this year after scientists from the institute and PacBio published a feasibility study this spring.
June 30, 2015 |
Clone-Free, Single-Molecule Genome Assembly Illuminates Structural Variation
A team of scientists has published one of the most detailed explorations to date of complex structural variation in a human genome. The results highlight just how much genomic variation is missed when working exclusively with short-read sequencing technologies.
June 29, 2015 |
Human Genome Sequenced without Cloning Steps
A collaboration of scientists led by researchers from Icahn School of Medicine at Mt. Sinai has created a comprehensive analysis of a diploid human genome using two complementary single DNA molecule methods for sequencing and genome mapping, and without the need for any DNA amplification techniques.
May 6, 2015 |
PacBio Explores Targeted Sequencing, Focusing on Complex Genomic Regions
Pacific Biosciences is making advances in the targeted sequencing space, including a partnership with Roche NimbleGen.
May 6, 2015 |
PacBio, RainDance Technologies Partner to Commercialize Whole-Genome Assembly Solution
The approach should allow “haplotype phas[ing] and assembly of complex regions even in genomic regions containing complex repeats or PCR-challenged sequences that limit the performance of other synthetic long read approaches based on short read sequencing technologies”.
May 6, 2015 |
PacBio, RainDance to Co-Develop De Novo Whole Genome Assembly Product
These solutions will combine the power of RainDance’s proprietary digital droplet technology and single-molecule barcoding capabilities with Pacific Biosciences’ proprietary long-range DNA amplification technology to provide sample preparation upstream of PacBio’s long-read sequencing system.
April 20, 2015 |
Tapping the Yeast Genome
Cover Story – Researchers are bringing advanced technologies like SMRT Sequencing to improve the ancient art of beer brewing.
April 17, 2015 |
Baylor Team Aims for ‘Gold Standard’ in Structural Variant Calling
Researchers from Baylor College of Medicine reported in BMC Genomics how they employed multiple sequencing technologies, library preparations, assembly methods, and genome mapping tools to work toward creating a reference diploid genome long read data from PacBio was especially important.
March 3, 2015 |
PacBio at AGBT
Pacific Biosciences held a star-studded workshop to show off the feats that can be accomplished with its SMRT (Single Molecule, Real-Time) sequencers, the instruments of choice for recovering long-range structural information on the genome.
March 2, 2015 |
AGBT: WGS with PacBio Yields High-Quality Assemblies, IDs Important Structural Variants
As its throughput and average read length have continued to increase, customers have been using the technology for larger and larger genomes. Now, a number of customers are using the technology to de novo sequence whole human genomes, according to presentations at last week’s AGBT meeting.
March 1, 2015 |
When Whole Genome Sequencing Doesn’t Give Us the Whole Genome
As its throughput and average read length have continued to increase, customers have been using the technology for larger and larger genomes. Now, a number of customers are using the technology to de novo sequence whole human genomes, according to presentations at last week’s AGBT meeting.
February 1, 2015 |
Decoding the Unsequenceable
In case you’re not aware, the human genome is not completely sequenced. Regions of repeats and hard to decode sequence continue to elude scientists. And then there is the challenge of genetic variation. Nathan Blow looks at new technologies and methods that could help map these and other difficult-to-read stretches of DNA.
January 22, 2015 |
PacBio’s 2015 Technology Roadmap Includes Greater Output, Longer Reads, Better Data Analysis
Pacific Biosciences plans to increase the output of its sequencer about fourfold this year, further increase read length, and improve sample prep protocols and data analysis for several applications.