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Monday, May 21, 2018

Application Brochure: No-Amp targeted sequencing.

Due to technology limitations, repeat-expansion disorders have gone without the needed base-level resolution of the disease causative long repetitive elements. Enrichment of these hard-to-amplify genomic regions is now possible with our no-amplification (No-Amp) targeted sequencing method utilizing the CRISPR/Cas9 system.

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Monday, May 21, 2018

Epigenetics Application Brochure: Characterize the epigenetic landscape of your genome.

Single Molecule, Real-Time (SMRT) Sequencing directly detects DNA modifications by measuring variation in the polymerase kinetics of DNA base incorporation during sequencing. With high throughput, long reads, and the sensitivity to detect epigenetic modification without amplification or chemical conversions, the PacBio Systems offer scalable solutions for assessing DNA modifications in bacterial and eukaryotic genomes.

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Monday, May 21, 2018

Application Brochure: Microbial communities – Complex microbial populations simplified.

The ability to identify and understand the functions of the complex microbial populations living in, on, and around us requires comprehensive characterization of each community member. Long reads, high accuracy, and single-molecule resolution make Single Molecule, Real-Time (SMRT) Sequencing ideal for full-length 16S rRNA sequencing, long-read metagenomic profiling, and shotgun metagenomic assembly.

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Monday, May 21, 2018

Cancer Brochure: Discover the hidden landscape of cancer variants

To bring precision medicine to every patient, cancer researchers need a more comprehensive view of all the somatic variants in genes, transcripts and whole genomes that drive cancer biology. Single Molecule, Real-Time (SMRT) Sequencing delivers the read lengths, uniform coverage, and accuracy needed to access the complete size spectrum of driver mutations — from rare single nucleotide variants to complex structural variants. Full-length transcript sequencing brings clarity to tumor-specific isoform and splice variant expression, enabling the discovery of novel biomarkers for early detection, tumor stratification, treatment response, and drug resistance. With SMRT Sequencing, scientists gain new insight into the most…

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Monday, May 21, 2018

De Novo Assembly Brochure: Assembly Options for your SMRT Sequencing Data

De novo assembly using PacBio SMRT Sequencing is now the gold standard for generating contiguous, highly accurate reference genomes. The challenge of assembly is eased with PacBio long reads, and a wealth of bioinformatics tools have been developed and optimized for SMRT Sequencing. Whether you’re a genome expert who likes to run tools at the command line or you’d prefer assembly experts to deliver a polished assembly directly to you, PacBio has a solution to fit your needs.

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Monday, May 21, 2018

SMRT Analysis Brochure: Gain a deeper understanding of your sequencing data

The PacBio Platform includes an extensive software portfolio that employs key advantages of SMRT (Single Molecule, Real-Time) Sequencing technology: extraordinarily long reads, highest consensus accuracy, uniform coverage and simultaneous epigenetic characterization. Core elements of our analytical portfolio include SMRT Analysis software, DevNet and SMRT Compatible products.

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Monday, May 21, 2018

Targeted Sequencing Application Brochure: Capture your regions of interest in high resolution.

The PacBio Systems combine single-molecule resolution, long reads, and uniform coverage, to fully characterize genetic complexity — including structural variants, indels, copy number variants, micro-satellites, somatic variants, haplotypes, and phasing. Move beyond simply cataloging SNPs and target all types of variation across relevant genomic regions, including low complexity regions like repeat expansions, promoters, and flanking regions of transposable elements.

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Monday, May 21, 2018

Immunology Brochure: Invaluable insights into immunology.

In order to understand the molecular mechanisms governing the outcomes of disease, health and survival, immunologists have to characterize exceptionally complex genomic regions, like major histocompatibility complex (MHC), killer cell immune receptors (KIR), and the B and T-cell immune repertoire. Single Molecule, Real-Time (SMRT) Sequencing delivers the long read lengths, uniform coverage and high accuracy necessary to comprehensively and confidently resolve these immune sub-genomic regions. The granularity of data generated by PacBio® reads provides new access to imputation-free characterization of genes and haplotypes for invaluable genomic insights to advance disease association and evolutionary research.

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Monday, May 21, 2018

HLA Sequencing Application Brochure: Fully phased, allele-specific HLA sequencing – the perfect pair.

Single Molecule Real-Time (SMRT) Sequencing delivers reads that span the lengths of the majority of HLA class I and II genes. Unambiguously phase 4-field HLA types without imputation. With a more accurate and complete picture, gain deeper understanding of immune-related disease causality, graft-versus-host disease in hematopoietic transplantation, and drug hypersensitivity.

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Monday, May 21, 2018

Industrial Biotechnology Brochure: Fuel biotech discovery with confident characterization of microbes and their communities.

Industrial microbiologists rely on comprehensive genomic information to identify and develop complex biological products. Single Molecule, Real-Time (SMRT) Sequencing delivers a more complete view of individual organisms and microbial communities, fueling research for modern pharmaceutical discovery, environmental remediation, chemical commodity production, and agriculture products.

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Monday, May 21, 2018

Core Lab Brochure: The most trusted long-read technology

SMRT Sequencing is Smart Business. Scientists rely on long-read sequencing to generate high-quality reference genomes, more accurate gene and transcript models, and an integrated view of the epigenome for their organisms of interest. Single Molecule, Real-Time (SMRT) Sequencing from PacBio is the most trusted long-read sequencing solution available today, delivering comprehensive genomic information for microbes, complex plant and animal genomes, and human biomedical research.

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Monday, May 21, 2018

Human Biomedical Research Brochure: The most comprehensive view of the human genome

To understand the genetic factors underlying health and disease and to address hidden heritability, scientists require a more comprehensive view of all the variations in the human genome. Single Molecule, Real-Time (SMRT) Sequencing delivers the read lengths, uniform coverage, and accuracy needed for accessing the complete size spectrum of sequence variant types — from single nucleotides to complex structural variants. PacBio’s long single-molecule reads also provide direct variant phasing information across full-length genes and chromosome haplotype blocks. With SMRT Sequencing, scientists gain new insight into the genetic basis of health and disease.

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