(Subscription required) Researchers who spoke during a panel discussion at the Festival of Genomics conference in San Mateo, California this week, said that although challenges continue to persist, they are more or less solvable as long as you know what the problem is and the correct technology to use to solve it.
Pacific Biosciences has launched a new nucleic acid sequencing platform called Sequel.
(Subscription required) At the American Society of Human Genetics annual meeting in Baltimore last week, PacBio Chief Scientific Officer Jonas Korlach and Executive Vice President and Chief Financial Officer Susan Barnes offered additional insights into the design and roll-out of the new platform.
Pacific Biosciences has launched a new single-molecule sequencing system that offers higher throughput and costs about half the price of its RS II system.
The Sequel System provides higher throughput, more scalability, a reduced footprint and lower sequencing project costs compared to the PacBio RS II System, while maintaining the existing benefits of the company's SMRT Technology.
(Subscription required) PacBio laid out plans to change the output of its instrument and analysis software packages from the Hierarchical Data Format (HDF5) to the more commonly used Binary Alignment/Map (BAM) file format for both raw and aligned sequencing reads.
Geneticists have a dirty little secret. More than a decade after the official completion of the Human Genome Project, and despite the publication of multiple updates, the sequence still has hundreds of gaps - many in regions linked to disease. Now, several research efforts are closing in on a truly complete human genome sequence, called the platinum genome.
A worldwide team has used single-molecule, real-time sequencing on a haploid sample to close gaps in the human reference genome and get a more complete view of the structural and sequence variation present in it.
The Suqian Lakeside Pangu Gene Company in Tianjin, China, has established a new genomics facility for translational medicine research projects and will use the PacBio RS II as its major sequencing platform.
Pacific Biosciences said last week that it received a record of 16 instrument orders in the third quarter from customers in a broad range of markets, including microbiology, ag-bio, HLA, and human sequencing.
To mangle the old saw, there's more than one way to sequence a transcriptome. For some researchers, the goal is counting transcripts to assess expression levelsÛÓa sequencing-based alternative to DNA microarrays. Others are interested in transcript architecture. Eukaryotic genes are often alternatively spliced, and the choice to include or exclude particular exons can have profound biological consequences.