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Capture regions of interest in high resolution

Combining PacBio long-read sequencing with targeted sequence capture provides a powerful tool for a comprehensive view of specific genomic regions of interest, regardless of size.

Flexible workflows for all your important genomic targets

Single Molecule, Real-Time (SMRT) Sequencing offers a flexible solution for targeting regions of interest and delivers the most comprehensive view of the associated genes using highly accurate long reads (HiFi reads). SMRT Sequencing gives you the ability to:

  • Rapidly screen and identify all variants
  • Discover haplotype-specific markers
  • Resolve difficult-to-sequence regions, regardless of size
  • Confirm insertion sites of transgenes and validate gene editing events

Interested in using an amplification-free approach? Explore No-Amp targeted sequencing to enrich and sequence hard-to-amplify genomic regions.

Workflow: from sample to base-level resolution

 

Sample & Library Preparation
Obtain targeted sequences with flexible sample and library workflows

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Sequencing
Maximize output and turn-around time with adjustable run parameters on the Sequel Systems.

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Data Analysis
Make discoveries using bioinformatics tools with the PacBio analytical portfolio.

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Application Brief: Learn more about these best practices for targeted sequencing of amplicons.

 

 

 


Mapping the NLRome: Research Teams Turn to SMRT Sequencing to Trace Plant Immunity

In a recent paper, a multi-institutional team detailed their creation of a nearly complete species-wide database of nucleotide-binding leucine-rich repeat receptors, or NLRs, in Arabidopsis thaliana. The sequences they obtained allowed them to define the core NLR complement, as well as to chart integrated domain diversity, describe new domain architectures, assess presence or absence of polymorphisms in non-core NLRs, and map uncharacterized NLRs onto the A. thaliana Col-0 reference genome. Explore this research further:

Van de Weyer, A.-L., et al. (2019). A Species-Wide Inventory of NLR Genes and Alleles in Arabidopsis thaliana. Cell, 178(5), 1260–1272.e14.

Spotlight: SMRT Sequencing Reveals Biodiversity

“The Sequel II represents a key component in the support infrastructure for BIOSCAN, a new seven-year $180 million research program which will advance our understanding of biodiversity by accelerating species discovery, and by revealing species interactions and dynamics. Given our plans to barcode tens of millions of specimens, it’s critical that analytical costs be reduced and the Sequel II makes this possible while also delivering very high fidelity sequences.”

Explore this news further here.

To learn more about how SMRT Sequencing can give you the long view of your targeted regions, contact us.

Selected Resources