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Tuesday, May 31, 2016

AACR Recap: Cancer Transcriptomes and a Moonshot Initiative

The PacBio team headed to New Orleans this past April to take in all the exciting new research presented at the American Association for Cancer Research Annual Meeting, show off our new Sequel instrument, and of course enjoy some crawfish and beignets! On the first day of the conference, we had the pleasure of hearing a talk from last year’s AACR “What Will You Discover About Cancer?” SMRT Grant winners, Malgorzata Komor and Remond Fijneman from the Netherlands Cancer Institute. Malgorzata discussed her work to identify novel biomarkers to identify precursor lesions in colorectal cancer, which can be integrated into…

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Thursday, May 26, 2016

Save the Spuds: UK Team Identifies Blight-Resistance Genes with SMRT Sequencing

Potato with late blight disease Scientists from the UK published new work detailing important advances in protecting potatoes from the disease that caused the Irish potato famine in the 1800s. It’s not just of historical interest; the team points out that late blight disease is once again endangering the food supply, with global yields of potatoes shrinking in recent years. “Accelerated cloning of a potato late blight–resistance gene using RenSeq and SMRT sequencing,” published in Nature Biotechnology, comes from lead authors Kamil Witek and Florian Jupe, senior author Jonathan Jones, and collaborators at The Sainsbury Laboratory and The Genome Analysis…

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Wednesday, May 18, 2016

Discover New Insights into Human Genetic Variation at ESHG in Barcelona

The PacBio team is looking forward to joining 3,000 other scientists in Barcelona May 21-24 for the European Human Genetics Conference, better known as ESHG.  Organized by the European Society of Human Genetics, this is the 49th year of a high-quality meeting where the latest developments in human and medical genetics are discussed. This year, we’ll be showcasing our new Sequel System at booth #260 in the exhibit hall. Come visit us and learn more about it! With higher throughput than our previous instrument, we think the Sequel System will be a great fit for the genomics community on projects…

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Tuesday, May 17, 2016

Arizona Scientists Deploy BAC Expertise and SMRT Sequencing for Crop Genomes

At the University of Arizona, a leading genomics research facility benefits from decades of BAC-based sequencing expertise, original studies of crop genomes, and a unique emphasis on high molecular weight DNA. Rod Wing, founding director of the Arizona Genomics Institute (AGI) and a professor in the School of Plant Sciences, Ecology & Evolutionary Biology at the university, was a pioneer in building BAC-based reference genomes in the ’90s. Today, that carefully honed expertise in isolating large DNA fragments gives him and his lab a real advantage for making the most of long-read sequencing. Wing’s efforts primarily focus on plant genomes,…

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Thursday, May 12, 2016

From Seabass to Salmon:
Swimming in High-Quality Genomes

Asian seabass A global collaboration of researchers has produced what is likely the most contiguous assembly of a fish genome to date. “Chromosomal-Level Assembly of the Asian Seabass Genome Using Long Sequence Reads and Multi-layered Scaffolding,” published in PLoS Genetics, comes from lead author Shubha Vij and senior author László Orbán with collaborators at nearly two dozen labs. The team set out to sequence Lates calcarifer, the Asian seabass, which has a genome of about 670 Mb grouped into 24 A chromosomes and as many as 10 B chromosomes. They used SMRT Sequencing from PacBio to overcome the fragmented and incomplete…

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Wednesday, May 4, 2016

Eco-friendly Soil Remediation Gets a Boost with the Latest SMRT Grant Program Winner

Congratulations to the winner of the first-ever SMRT Grant program decided by the community: Renying Zhuo of the Chinese Academy of Forestry! We ran polling through our Genome Galaxy Initiative on the Experiment crowdfunding platform and were amazed to see much how it galvanized the genomics community. There were 30,000+ responses to the competition across the five finalists for our “Explore Your Most Interesting Genome” grant opportunity. Zhuo garnered the most support for his project to sequence two highly related strains of Sedum alfredii for a comparative genomics investigation to identify key genes important for remediating soil contaminated by heavy…

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Monday, May 2, 2016

Join the SMRT Community: User Meetings in Europe, Asia, and the US

There are several PacBio user meetings coming up, and with locations around the world we hope you’ll be able to attend one of them. These meetings are a great way to meet fellow customers, exchange tips, and learn about new applications. If you are interested, please register as soon as possible to reserve your seat.   The Netherlands: SMRT Leiden Symposium & Informatics Developers Meeting, June 6-8 This meeting, organized and hosted by Leiden University Medical Center’s human genetics department, includes a scientific symposium and the first SMRT Informatics Developers meeting in Europe. There’s an impressive agenda for the two-day…

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