Wednesday, March 30, 2016

New Study Uses SMRT-ChIP Method to Find Novel Methylation in Mouse Embryonic Stem Cells

In a new Nature publication, scientists from Yale and other institutions report the discovery of N6-methyladenine (N6-mA) in mouse embryonic stem cells (ESCs), contrary to the conventional wisdom that the only form of methylation in mammals is 5-methylcytosine. Through the project, the team also developed a new method for pairing chromatin immunoprecipitation (ChIP) with SMRT Sequencing. Both of these developments have significant implications for the genomics community. “DNA methylation on N6-adenine in mammalian embryonic stem cells” comes from lead author Tao Wu and senior author Andrew Xiao, both at Yale School of Medicine. The team also included collaborators from the…

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