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お問い合わせ

新たな生物学の発見の入り口


エピジェネティクスの修飾は遺伝子発現、宿主病原体相互作用、環境応答、DNAダメージおよび修復など、多岐にわたる生物学プロセスに影響をもたらします1。エピジェネティクスはまた次の世代へ形質を遺伝する際に重要な役割をもちます。20種類以上ものエピジェネティクスおよびDNAダメージ修飾が同定されていますが、これまでシトシンメチル化の1種類のみが研究され、しかも間接的な検出手法が用いられていました。自然の生物学プロセスや疾患応答匂いてDNA修飾のインパクトを理解するのに、これらのエピジェネティクス変化の直接検出が求められています。

ゲノムのエピジェネティクスな特徴づけ

PacBioの1分子リアルタイム(SMRT)シークエンスは、塩基取り込み時の反応変化を測定することでエピジェネティクス修飾を直接検出することができます。シークエンス情報と同時にこれらの修飾情報を手に入れることができるので、特別なサンプル調製や追加のシークエンスを必要としません。

 

PacBioシステムが直接検出するエピジェネティクス修飾の像

SMRTシークエンスで検出できる主要なエピジェネティクス修飾

 

Epigenetics.Spotlight.Epigenetic-Modifications-Image

SMRTシークエンスでどのようにゲノムそしてエピジェネティクス情報を入手できるか、詳細はお問い合わせください。

 

Reference

  1. Davis, B. M., et al., (2013) Entering the era of bacterial epigenomics with single molecule real time DNA sequencing. Current Opinion in Microbiology. 16 (2), 192–198.

Selected Resources