(Subscription required) – Researchers at Baylor College of Medicine are exploring whether PacBio long sequence reads can detect genetic disease mutations that would otherwise go unnoticed.
Aaron Krol provides an in-depth look at the use of SMRT Sequencing at the Icahn School of Medicine at Mount Sinai.
PacBio’s own Luke Hickey provides an overview of efforts to create reference-quality human genomes in this contributed article.
The genome of Tardigrades, or water bears, was decoded using PacBio sequencing revealing how they are a ‘sponge’ for foreign genes.
Researchers reported in Nature the virtually complete draft genome of Oropetium thomaeum, a grass species that can regrow after exposed to extreme drought when water becomes available.
(Subscription required) Researchers who spoke during a panel discussion at the Festival of Genomics conference in San Mateo, California this week, said that although challenges continue to persist, they are more or less solvable as long as you know what the problem is and the correct technology to use to solve it.
Pacific Biosciences has launched a new nucleic acid sequencing platform called Sequel.
(Subscription required) Pacific Biosciences said that in the first two weeks since it launched its Sequel System, it has received as many requests for quotes as it did collectively in the prior nine months for its RS II system, and several of those requests have turned into sales.
Sequencing is becoming less ambiguous and more clinically relevant with advances in technology.
(Subscription required) At the American Society of Human Genetics annual meeting in Baltimore last week, PacBio Chief Scientific Officer Jonas Korlach and Executive Vice President and Chief Financial Officer Susan Barnes offered additional insights into the design and roll-out of the new platform.
Pacific Biosciences has launched a new single-molecule sequencing system that offers higher throughput and costs about half the price of its RS II system.
The Sequel System provides higher throughput, more scalability, a reduced footprint and lower sequencing project costs compared to the PacBio RS II System, while maintaining the existing benefits of the company’s SMRT Technology.
(Subscription required) PacBio laid out plans to change the output of its instrument and analysis software packages from the Hierarchical Data Format (HDF5) to the more commonly used Binary Alignment/Map (BAM) file format for both raw and aligned sequencing reads.
While not about PacBio specifically, we thought this editorial would be of interest to the SMRT Sequencing community.
(Subscription required) During a conference call discussing its second quarter performance, CEO Mike Hunkapiller gave an overview of the single-molecule sequencing company’s position in the market and expansion plans.