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At AACR, Revealing Structural Variants and a New SMRT Grant Program

Thursday, March 30, 2017

We’re excited to be heading to Washington, DC, for the annual meeting of the American Association for Cancer Research. The PacBio team always enjoys hearing about the latest in cancer translational research at AACR, along with thousands of leading scientists in the field.

AACR 2017

Many of those scientists have already learned that SMRT Sequencing provides a unique view into cancer, revealing structural variation, phasing distant variants, and delivering full-length isoform sequences. With uniform coverage, industry-leading consensus accuracy, and reads extending to tens of kilobases, PacBio long-read sequencing gives researchers the ability to monitor and make sense of even the most complex changes in tumor DNA.

If you’ll be attending AACR, stop by booth #1617 to get a first look at the new Integrative Genomics Viewer (IGV v3) featuring greatly improved support for SMRT Sequencing data. We’ll be demonstrating the new features in IGV v3 with a PacBio whole genome sequencing dataset (the SK-BR-3 Human Breast Cancer cell line). Visit us to see how PacBio data visualized in IGV v3 reveals the hidden landscape of somatic structural variants in a cancer genome including translocations, gene fusions, and novel mobile element insertion sites.

In addition, check out these posters from our scientists to see SMRT Sequencing data in action for cancer studies:

SMRT Sequencing of Full-length Androgen Receptor Isoforms in Prostate Cancer Reveals Previously Hidden Drug Resistant Variants
Tyson Clark, Ph.D., PacBio
Sunday, April 2, 1 p.m. – 5 p.m., Abstract #425/25, Section 17

Simplified Sequencing of Full-length Isoforms in Cancer on the PacBio Sequel System
Meredith Ashby, Ph.D., PacBio
Monday, April 3, 1 p.m. – 5 p.m., Abstract #2442/29, Section 17

Detection of Low-frequency Somatic Variants using Single-molecule, Real-time Sequencing
Primo Baybayan, PacBio
Wednesday, April 5, 8 a.m. – 12 p.m., Abstract #5366/22, Section 15

Finally, we’ll be launching a new SMRT Grant program at AACR. Just tell us how full-length isoform sequencing of your cancer samples will drive new discoveries in your research for a chance to win library construction, PacBio sequencing, and bioinformatics analysis for your project. Check out the rules and submit your 250-word proposal by May 15. Many thanks to our partner GENEWIZ for helping us make this grant program possible!

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